Citron homology

WebHomology more Human Ortholog CIT, citron rho-interacting serine/threonine kinase Vertebrate Orthologs 3 Human Diseases more Diseases 1 with human CIT associations Mutations, Alleles, and Phenotypes less Phenotype Summary 26 phenotypes from 2 alleles in 2 genetic backgrounds 24 phenotype references Phenotype Overview WebOct 22, 2024 · MAP4K family kinases such as MAP4K3 (GLK) and MAP4K1 (HPK1) are composed of a kinase domain (KD), proline-rich motifs in the middle region, and a citron-homology (CNH) domain. The autophosphorylation sites of GLK and HPK1 are phospho-Ser-170 residue and phospho-Ser-171 residue, respectively.

MINK and TNIK Differentially Act on Rap2-Mediated Signal …

WebBased on sequence similarities a domain of homology has been identified in the following proteins [ (PUBMED:10391936) ]: Citron and Citron kinase. These two proteins interact with the GTP-bound forms of the small GTPases Rho and Rac but not with Cdc42. … Browse the database of all available domains in the SMART database; … Option Setting; Home page options: Use SMART in 'Genomic mode' "Outlier … Weernink PA et al.; Activation of type I phosphatidylinositol 4-phosphate 5 … The process of constructing SMART predicted (i) novel domain homologues … FAQ 1. Can I run SMART locally? SMART is composed of several different … WebSep 21, 2024 · Rom2, the guanine nucleotide exchange factor to Rho1, contains a C-terminal citron homology (CNH) domain of unknown function that is found in many other … imyfone converter download free https://mckenney-martinson.com

The citron homology domain as a scaffold for Rho1 …

WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH 2 terminus is unique to the … WebCitron homology (CNH) domain CRIB domain KELK-motif containing domain Myotonic dystrophy protein kinase, coiled coil PH-like domain superfamily Pleckstrin homology … WebNov 15, 2011 · The predicted structure of Gek includes a serine/threonine kinase (STK) catalytic domain, a coiled-coil (CC) domain, a cysteine-rich region (CR), a pleckstrin homology (PH) domain, a citron homology (CH) domain and a Cdc42/Rac interactive binding (CRIB) domain (Luo et al., 1997) (supplementary material Fig. S1). imyfone converter free

MINK and TNIK Differentially Act on Rap2-Mediated Signal …

Category:Human Vam6p promotes lysosome clustering and fusion in vivo

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Citron homology

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple ...

WebMar 2, 2024 · This protein is localized to the plasma membrane by means of the citron homology domain, where the middle region binds to CK2, thus preventing it from … WebTreatment of mice with orally available HPK1 inhibitors results in increased activation of antigen- specific CD8+T cells in vivo and decreased tumor growth as single agent and in …

Citron homology

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WebMar 2, 2024 · This protein is localized to the plasma membrane by means of the citron homology domain, where the middle region binds to CK2, thus preventing it from phosphorylating PTEN. This activated PTEN downregulates phosphatidylinositol (3,4,5)-trisphosphate, an important driving factor of AKT signaling. Reduced AKT signaling leads … WebJun 11, 2024 · The Ser/Thr kinase MAP4K4, like other GCKIV kinases, has N-terminal kinase and C-terminal citron homology (CNH) domains. MAP4K4 can activate c-Jun N …

WebOct 6, 2016 · 它们并无 RA 结构域而是 CNH 结构域（citron homology domain）其中，MAP4K4 可通过调节生长因子及整联蛋白调节细胞转化，促 进细胞侵袭，降低细胞粘 … WebMay 1, 2005 · Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20 …

WebKD, kinase domain; ID, intermediate domain; CNH, citron homology domain; CC, coiled-coil. Lower: Co-IP and IB analysis of STRN4 and STRIP1 in DAOY cells transduced with lentiviral vectors expressing full-length or truncated MAP4K4-FLAG. Asterisks indicate relevant bands. i Quantification of co-IP from H ( n = 3, means ± SEM). WebHuman TNIK is a 1360-residue protein consisting of an N-terminal kinase domain, an intermediate domain, and a Cterminal domain conserved in the GCK family, which is termed the citron homology (CNH ...

http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00036

WebAug 12, 2024 · Gene description. CNH domain-containing protein;Vacuolar protein sorting-associated protein 39 homolog. Primary source. … in8191h01013WebBoth phosphorylation of Ser-348 and BLUS1 kinase activity are essential for activation of the H (+)-ATPase. blus1 mutants show lower stomatal conductance and CO2 assimilation than wild-type plants under decreased ambient CO2. Together, our analyses demonstrate that BLUS1 functions as a phototropin substrate and primary regulator of stomatal ... in8 trowbridgeWebBased on sequence similarities a domain of homology has been identified near the N- or C-terminal end of the following proteins [1,2,3]: Citron Rho-interacting kinase … in8214t01018WebNov 19, 2004 · TNIK possesses an N-terminal kinase domain homologous to STE20, the Saccharomyces cerevisiae mitogen-activated protein kinase kinase kinase kinase, and … in8 photography galleryWebNov 6, 1998 · We have identified a novel serine/threonine kinase belonging to the myotonic dystrophy kinase family. The kinase can be produced in at least two different isoforms: a approximately 240-kDa protein (Citron Rho-interacting kinase, CRIK), in which the kinase domain is followed by the sequence of Citron, a previously identified Rho/Rac binding … in8 softwareWebMost importantly, MRCKs, ROCKs, and CRIK contain a number of additional protein domains with distinct functions, including a small GTPase binding domain, a PH domain, a cysteine-rich domain, and a citron homology domain. It is this lack of motifs with known function that renders DMPK unique among its family members and in the AGC group as … in8 wellness north andoverWebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH(2) terminus is unique to the … in8 cards