WebApr 4, 2024 · Recent studies have proved that IRF6, regulated by TP63, plays a tumor suppressor role in squamous cell carcinomas through a Notch-dependent mechanism ( 8 … WebIRF6 is a transcription factor that belongs to a family of nine transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein-binding domain. Most IRFs regulate the expression of interferon-alpha and -beta after viral infection, but the function of IRF6 is related to epidermal development. –
IRF6 gene: MedlinePlus Genetics
WebMay 3, 2024 · Inhibition of KIF20A by transcription factor IRF6 affects the progression of renal clear cell carcinoma Abstract. Renal clear cell carcinoma (ccRCC) is one of the most … IRF6 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. Similarly, IRF6 has been found to be genetically and epigenetically disregulated in Vulvar cancer. popular now spain
Inhibition of KIF20A by transcription factor IRF6 affects …
WebJun 21, 2024 · The findings of this study indicate that IRF6 is downregulated in highly malignant human and mouse breast cancer cell lines. Also, the modulation of the … WebAug 23, 2013 · Non-syndromic oral clefts and risk of cancer: a systematic review Daniela Araújo Veloso Popoff, Mateus Prates Coelho, Daniella Reis Barbosa Martelli, Rajiv Saini, Ricardo Della Coletta, Hercílio Martelli-Júnior ... Lack of association between IRF6 polymorphisms and nonsyndromic oral clefts in South Indian population Venkatesh Babu ... WebAug 19, 2016 · IRF6 -related disorders are a group of orofacial clefting disorders including Van der Woude syndrome (VWS) and popliteal pterygium syndrome (PPS). These conditions are caused by mutations in the interferon regulatory factor 6 ( IRF6) gene. Individuals with VWS are at the least severe end of the spectrum. shark reconnaissance uav