Lithoplocamia lithistoides
Web17 mrt. 2024 · Plocabulin (PM060184/PM184, PharmaMar) is a compound of marine origin derived from the Madagascan sponge Lithoplocamia lithistoides. Plocabulin belongs to a family of tubulin-binding agents that inhibits tubulin polymerization by binding to the dimer’s end, with one of the highest known affinities among tubulin-binding agents. WebGlobal Biodiversity Information Facility. Free and Open Access to Biodiversity Data.
Lithoplocamia lithistoides
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Web21 jan. 2024 · Kahalalide F has displayed potent cytotoxicity against cancer cells of the breast (BT-474, MCF7, MDA-231, and SK-BR-3), colon (HT29 and LoVo), liver (Hep G2), lung adenocarcinoma (A549), ovaries,... Web7 dec. 2024 · Plocabulin (PM184; Fig. 8) and its chloro-derivative (Fig. 8; PM-050489) were isolated by PharmaMar scientists from the sponge Lithoplocamia lithistoides, but due to the low levels in the extract, both …
Web11 jun. 2024 · Lithoplocamia lithistoides Dendy, 1922. Accessed through: Odido, M.; Appeltans, W.; BelHassen, M.; Mussai, P.; Nsiangango, S.E.; Vandepitte, L.; Wambiji, …
WebGenus: Lithoplocamia Species (6): L. atlantica – L. dolichosclera – L. indica – L. lithistoides – L. minor – L. tuberculata. Name . Lithoplocamia Dendy, 1922 References … WebPM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research [1] [2] . PM050489 inhibits the activity of HT-29, A-549 and MDA-MB-231 cells ...
WebLithoplocamia lithistoides (Q2418850) From Wikidata. Jump to navigation Jump to search. species of sponge. edit. Language Label Description Also known as; English: …
WebLithoplocamia is een geslacht van sponsdieren uit de klasse van de Demospongiae (gewone sponzen). 7 relaties: Lithoplocamia atlantica , Lithoplocamia dolichosclera , … kenyon plastering ontario caWeb10 jul. 2013 · Paclitaxel is arguably the most well-known and commercially successful mitosis inhibitor; intriguingly, these new compounds isolated from the Madagascan sponge Lithoplocamia lithistoides show a distinct biochemical mechanism of … is iran an authoritarian stateWeb29 feb. 2016 · PM184 is a marine -derive drug found in a sponge called Lithoplocamia lithistoides. This drug candidate is a microtubule inhibitor that targets a protein called tubulin in a novel way. It blocks cancer growth by impairing cell division of tumour cells through the inhibition of a crucial process called mitosis. kenyon mn weatherWeb11 dec. 2024 · At difference with the above cited phase II anticancer drugs, plocabulin (PM060184) is not an ADC but it is a Lithoplocamia lithistoides sponge-derived polyketide which acts as a very potent antimitotic agent, binding to a specific β-tubulin site with possible activity on tumors resistant to other tubulin inhibitors . is iran a monarchyWebLithoplocamia Click on organism name to get more information. Lithoplocamia lithistoides Disclaimer: The NCBI taxonomy database is not an authoritative source for nomenclature or classification - please consult the relevant scientific literature for the most reliable information. Reference: ... is iran a rich countryWebLithoplocamia lithistoides is een spons soort in de taxonomische indeling van de gewone sponzen (Demospongiae). Het lichaam van de spons bestaat uit kiezelnaalden en sponginevezels, en is in staat om veel water op te nemen. De spons behoort tot het … kenyon murray net worthWebPHASE I STUDIES First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors Elena Elez1 & Carlos Gomez-Roca2 & Arturo Soto Matos-Pita3 & Guillem Argiles1 & Thibaud Valentin2 & Cinthya Coronado3 & Jorge Iglesias3 & Teresa Macarulla1 & Sarah Betrian2 & Salvador Fudio3 & Katrin Zaragoza3 & Josep … is iran and iraq safavids and ottoman