Web17 rows · Phosphorothioate bonds can be introduced between the last 3-5 nucleotides at the 5'- or 3'-end of the oligo to inhibit exonuclease degradation. Including … WebSep 20, 2013 · Synthetic methods were investigated for the preparation of O and S-glucosyl thiophosphates and glucosyl 1C-thiophosphonate. Four protected glucosyl thiophosphate compounds were synthesized and characterized as precursors to glucose 1-thiophosphate. The effect of various reaction conditions and the n …
(PDF) Oligonucleotide inhibitors of telomerase: Prospects for ...
WebFor every thiophosphate linkage in a phosphorothioate oligonucleotide, a destabilization of the heteroduplex with complementary RNA of approximately - 0.7° C occurs, relative to parent DNA (16). This amounts to approximately 14° C destabilization in a 21 mer phosphorothioate, or approximately 3-4 orders of magnitude decrease in K d compared ... Web5' Thiophosphate - (O-0259) -->. This modification is available as part of a custom oligonucleotide configuration. Please use OLIGObuilder™ to generate pricing and order or contact us to speak with a customer service representative. steady rsl
Thiophosphate and thiophosphonate analogues of glucose-1
WebMar 1, 2015 · Thus, the thiophosphate oligonucleotide SODNS inhib ... We compared different oligonucleotide based methods for telomerase RNA inhibition, such as antisense oligonucleotides, knockdown by ... WebThe solid-phase strategy for oligonucleotide synthesis has been responsible for much of the widespread utilization of synthetic oligonucleotides. ... . and Thuong, N. T. (1989) Solid phase synthesis of modified oligodeoxyribonucleotides with an acridine derivative or a thiophosphate group at their 3′-end. Tetrahedron Lett. 30, 2521–2424 ... Monothiophosphate is the anion [PO3S]3−, which has C3v symmetry. A common salt is sodium monothiophosphate (Na3PO3S). Monothiophosphate is used in research as an analogue of phosphate in biochemistry. Monothiophosphate esters are biochemical reagents used in the study of transcription, … See more Dithiophosphate has the formula [PO2S2]3−, which has C2v symmetry. Sodium dithiophosphate, which is colorless, is the major product from the … See more Trithiophosphate is the anion [POS3]3−, which has C3v symmetry. Tetrathiophosphate is the anion [PS4]3−, which has Tdsymmetry. See more A number of these anions known. Some have attracted interest as components in fast ion conductors for use in solid state batteries. The binary thiophosphates … See more steady rollin man meaning